Clinical Validation

Journal Articles:

Comparison of human lung tissue mass measurements from Ex Vivo lungs and high resolution CT software analysis. Erik Henne, Joseph C Anderson, Norma Lowe and Steven Kesten. BMC Pulmonary Medicine 2012, 12:18 doi:10.1186/1471-2466-12-18. Published: 14 May 2012
download full text >>

Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease. Celli, B. R., Locantore, N., Yates, J., Tal-Singer, R., Miller, B. E., Bakke, P., Calverley, P., Coxson, H., Crim, C., Edwards, L. D., Lomas, D. A., Duvoix, A., MacNee, W., Rennard, S., Silverman, E., Vestbo, J., Wouters, E., Agusti, A., for the ECLIPSE I. Published ahead of print on March 15, 2012, doi:10.1164/rccm.201110-1792OCAm. J. Respir. Crit. Care Med.May 15, 2012 vol. 185 no. 10 1065-1072.
download full text >>

John Newell and Susan A. Wood. A Combined Pulmonary-Radiology Workshop for Visual Evaluation of COPD: Study Design, Chest CT Findings and Concordance with Quantitative Evaluation,COPD: Journal of Chronic Obstructive Pulmonary Disease, Volume 9, Number 2 (April 2012).
download >>

Bronchoscopic treatment of emphysema (Tratamento endoscópico do enfisema)

Hugo G. de Oliveira1,2, Silvia M. de Oliveira2, Amarilio V. de Macedo Neto1,2. Hospital de Clínicas de Porto Alegre, HCPA, Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre (RS) Brasil. Source: Pulmão RJ 2011;20(2):2-7.
view original abstract (Portugese) >>
view Google Translation >>

Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD,Silverman EK; the COPDGene Investigators.Clinical and Radiographic Predictors of GOLD-Unclassified Smokers in COPDGene. Source: Channing Laboratory and Pulmonary & Critical Care Division, Brigham & Women's Hospital, Boston, Massachusetts, United States. Am. J. Respir. Crit. Care Med., Volume 184, Number 1, July 2011, 57-63
view abstract>>

Kim V, Han MK, Vance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK, Criner GJ; the COPDGene® Investigators. THE CHRONIC BRONCHITIC PHENOTYPE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: An Analysis of the COPDGene Study.
Source: Temple University School of Medicine, Philadelphia, PA; Chest April 7, 2011 102948. Published ahead of print April 7, 2011.
view abstract >>

Gietema HA, Müller NL, Fauerbach PV, Sharma S, Edwards LD, Camp PG, Coxson HO; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators. Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Academic Radiology, Vol 18, No 6, June 2011
download >>

1. J.P. Williamson, J.J. Armstrong, R.A. McLaughlin, P.B. Noble, A.R. West, S. Becker, A. Curatolo, W.J. Noffsinger, H.W. Mitchell, M.J. Phillips, D.D. Sampson, D.R. Hillman, and P.R. Eastwood, Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography, European Respiratory Journal, 2010, 35, 34-41
download >>

2. E. A. Regan, J. E. Hokanson, J. R. Murphy, B. Make, D. A. Lynch, T. H. Beaty, D. Curran-Everett, E. K. Silverman, and J. D. Crapo for the COPD Gene Investigators, Genetic Epidemiology of COPD (COPDGene) Study Design, Journal of Chronic Obstructive Pulmonary Disease, 2010, Vol. 7, No. 1, 32-43
download >>

3. D. M. Hansell, P. M. Boiselle, J. Goldin, H.U. Kauczor, D. A. lynch, J. R. Mayo,  E. F. Patzjr, Thoracic Imaging, Respirology, 2010, Vol. 15, Issue 3, 393-400
download >>

4. K. Ding, J.E. Bayouth, J.M. Buatti, G.E. Christensen, J.M. Reinhardt, 4DCT-based Measurement of Changes in Pulmonary Function Following a Course of Radiation Therapy, Medical Physics, 2010, 37(3), 1261-1272
download >>

5.M.L. Ceridon, E.M. Snyder, N.A. Strom, J. Tschirren, and B.D. Johnson, Influence of Rapid Fluid Loading on Airway Structure and Function in Healthy Humans, Journal of Cardiac Failure, Vol. 16, No. 2, 2010, 175-185
download >>

6. Xia G, Tawhai MH, Hoffman EA, Lin CL. Airway Wall Stiffening Increases Peak Wall Shear Stress: A Fluid-Structure Interaction Study in Rigid and Compliant Airways. Ann Biomed Eng. 2010 Feb 17. [Epub ahead of print] PubMed PMID: 20162357
download >>

7. D. Singh, L. Edwards, R. Tal-Singer, and S. Rennard, Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study, Respiratory Research, 2010, 11:77
download >>

8. Sara K. Alforda,b, Edwin J. R. van Beeka,b,c, Geoffrey McLennana,b,c, and Eric A. Hoffman. Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokers. PNAS April 20, 2010 vol. 107 no. 16 7485-7490
download >>

9. Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, Jiang R, Kawut SM, Kronmal RA, Lima JA, Shahar E, Smith LJ, Watson KE. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med. 2010 Jan 21;362(3):217-27. PubMed PMID: 20089972.
download >>

10. Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly JJ, Silverman EK. Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respir Res. 2010 Mar 16;11(1):30. [Epub ahead of print] PubMed PMID: 20233420.
download >>

11. Lovasi GS, Diez Roux AV, Hoffman EA, Kawut SM, Jacobs DR Jr, Barr RG. Association of environmental tobacco smoke exposure in childhood with early emphysema in adulthood among nonsmokers: the MESA-lung study. Am J Epidemiol. 2010 Jan 1;171(1):54-62. Epub 2009 Nov 25. PubMed PMID: 19942575; PubMed Central  PMCID: PMC2800303.
download >>

12. Choi J, Tawhai MH, Hoffman EA, Lin CL. On intra- and intersubject variabilities of airflow in the human lungs. Phys Fluids (1994). 2009 Oct;21(10):101901. Epub 2009 Oct 13. PubMed PMID: 19901999; PubMed Central PMCID: PMC2774343.
download >>

13. Washko GR, Martinez FJ, Hoffman EA, Loring SH, Estépar RS, Diaz AA, Sciurba FC, Silverman EK, Han MK, Decamp M, Reilly JJ; National Emphysema Treatment Trial Research Group. Physiological and computed tomographic predictors of outcome from lung volume reduction surgery. Am J Respir Crit Care Med. 2010 Mar 1;181(5):494-500. Epub 2009 Dec 3. PubMed PMID: 19965810; PubMed Central PMCID: PMC2830400.
download >>

14.V. Kim, R. Steiner, Interventional Treatment Options for Advanced Emphysema: Imaging Manifestations, Journal of Thoracic Imaging: 2009, Vol. 24, Issue 3, 195-205
download >>

15. H. O. Coxson and S. Lam, Quantitative Assessment of the Airway Wall Using Computed Tomography and Optical Coherence Tomography, The Proceedings of the American Thoracic Society 6:439-443 (2009)
download >>

16. H. O. Coxson, J. Mayo, S. Lam, G. Santyr, G. Parraga, and D. D. Sin, New and Current Clinical Imaging Techniques to Study Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine, 2009, Vol. 180. pp. 588-597
download >>

17. G. I. Snell, P. Hopkins, G. Westall, L. Holsworth, A. Carle, and T. J. Williams, A Feasibility and Safety Study of Bronchoscopic Thermal Vapor Ablation: A Novel Emphysema Therapy, The Annals of Thoracic Surgery, Vol. 88, Issue 6, 2009, 1993-1998
download >>

18. Y. Refaely, M. Dransfield, M. R. Kramer, M. Gotfried, W. Leeds, G. McLennan, S. Tewari, M. Krasna, G.J. Criner, Biologic Lung Volume Reduction (BioLVR) Therapy for Advanced Homogeneous Emphysema, European Respiratory Journal, 2009, Vol. 19 1-24
download >>

19. Y. B. Yin, C. L.  Lin, and E.A. Hoffman, Mass Preserving Nonrigid Registration of CT Lung Images Using Cubic B-spline, Medical Physics, 2009, 36, 4213-4223
download >>

20. A. W. Sheel, J. A. Guenette, R. Yuan, L. Holy, J. R. Mayo, A. M. McWilliams, S. Lam,  and H. O. Coxson, Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers, J Applied Physiology, 2009, Vol. 107, 1622-1628   (Authors are from University of British Columbia, Vancouver General Hospital, etc. )
download >>

21. E. Namati, M. J. Suter, and G. McLennan, Endoscopic Techniques for Optical Imaging, Optical Imaging of Cancer, 2009, 25-48
download >>

22. A. Busacker, J. D. Newell, T. Keefe, E. A. Hoffman, J. C. Granroth, M. Castro, S. Fain, S. Wenzel, A Multivariate Analysis of Risk Factors for the Air-Trapping Asthmatic Phenotype as Measured by Quantitative CT Analysis, CHEST, Jan. 2009, vol. 135, No. 48-56
download >>

23. D. A. Lomas, E. K. Silverman, L. D. Edwards, N. W. Locantore, B. E. Miller, D. H. Horstman, R. Tal-Singer and on behalf of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study investigators, Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPDEuropean Respiratory Journal, 2009, 34: 95-102
download >>

24.Busacker A, Newell JD Jr, Keefe T, Hoffman EA, Granroth JC, Castro M, Fain S, Wenzel S.A Multivariate analysis of risk factors for the air-trapping asthmatic  phenotype as measured by quantitative CT analysis. Chest. 2009 Jan;135(1):48-56. Epub 2008 Aug 8. PubMed PMID: 18689585.
download >>

25. E.J.R. van Beek, E.A. Hoffman, Imaging in COPD, Imaging Decisions MRI, 2009, Vol.13, Issue 1, pp. 11-17
download >>

26.S. B. Fain, E. T. Peterson, R. L. Sorkness, S. Wenzel, M. Castro, W. W. Busse, Severe Asthma Research Program –Phenotyping and Quantification of Severe Asthma, Imaging Decisions MRI, 2009, Volume 13 Issue 1, Pages 24 - 27
download >>

27. J. Tschirren, T. Yavarna, and J. M. Reinhardt, Airway Segmentation Framework for Clinical Environments, EXACT'09, 227-238
download >>

28. X.M. Liu, D.Z. Chen, M. Tawhai, E. Hoffman, M. Sonka, Measurement, Evaluation, and Analysis of Wall Thickness of 3D Airway Trees across Bifurcations, Proceedings of Second International Workshop on Pulmonary Image Processing, 2009, 161-171
download >>

29. Hoffman EA, Jiang R, Baumhauer H, Brooks MA, Carr JJ, Detrano R, Reinhardt J, Rodriguez J, Stukovsky K, Wong ND, Barr RG. Reproducibility and validity of lung density measures from cardiac CT Scans--The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Acad Radiol. 2009 Jun;16(6):689-99.PubMed PMID: 19427979.
download >>

30. Lederer DJ, Enright PL, Kawut SM, Hoffman EA, Hunninghake G, van Beek EJ, Austin JH, Jiang R, Lovasi GS, Barr RG. Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-lung study. Am J Respir Crit Care Med. 2009 Sep 1;180(5):407-14. Epub 2009 Jun 19. PubMed PMID: 19542480; PubMed Central PMCID: PMC2742759.
download >>

31.H. O. Coxson, B. Quiney, D. D. Sin, L. Xing, A. M. McWilliams, J. R. Mayo and S. Lam, Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography, American Journal of Respiratory and Critical Care Medicine, Vol. 177, pp. 1201-1206, 2008
download >>

32.H. O. Coxson, Quantitative Computed Tomography Assessment of Airway Wall Dimensions, The Proceedings of the American Thoracic Society 5: 940-945 (2008)
download >>

33. Edwin J.R. van Beek, E.A. Hoffman, Functional Imaging: CT and MRI, Clinics in Chest Medicine, Vol. 29, Issue 1, March 2008, pp. 195-216
download >>

34. D.A. Lomas, E.K. Silverman, L.D. Edwards, B.E. Miller, H.O. Coxson, R. Tal-Singer, Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort, Thorax 2008;63:1058-1063
download >>

35. D. Baratz, L.Y. Fu, J.B. Ross, E. Ingenito, M. H. Gotfried, Endobronchial Biologic Lung Volume Reduction (BLVR) Therapy for Unilateral Bullous Emphysema, Journal of Bronchology: 2008, Vol. 15, Issue, 268-272
download >>

36. R. S. Aysola, E. A. Hoffman, D. Gierada, S. Wenzel, J. Cook-Granroth, J. Tarsi, J. Zheng, K. B. Schechtman, T. P. Ramkumar, R. Cochran, E. Xueping, C. Christie, J. Newell, S. Fain, T. A. Altes, and M. Castro, Airway Remodeling Measured by Multi-detector CT is Increased in Severe Asthma and Correlated with Pathology, 2008, CHEST vol. 134 no. 6 1183-1191
download >>


37. S. Asthm, S.Fain, T. A. Altes, M. Castro and Research Program (SARP) NHLBI, P. Ramkumar, R. Cochran, E Xueping, C. Christie, J. Newell, Cook-Granroth, J. Tarsi, J. Zheng, K. B. Schechtman, Thiruvamoor, R. S. Aysola, E. A. Hoffman, D. Gierada, S. Wenzel, Janice, Airway Remodeling Measured by Multidetector Computed Tomography Is Increased in Severe Asthma and Correlates with Pathology, CHEST; Pre-published online July 18, 2008
download >>

38. Y. S. Tzeng, E. A. Hoffman, J. Cook-Granroth, J. Gereige, J. Mansour, G. Washko, M. Cho, E. Stepp, K. Lutchen, and M. Alber, Investigation of Hyperpolarized 3He MRI Utility in Examining Human Airway Diameter Behavior in Asthma through Comparison with High-Resolution Computed Tomography, Academy Radiology, 2008 June, 15(6), 799-808
download >>

39.G. McLennan, E. Namati, J. Ganatra, M. Suter, E.E. O'Brien, K. Lecamwasam, E.F.R. van Beek, E.A.Hoffman, Virtual Bronchoscopy, Imaging Decisions MRI, 2007, Vol. 11, Issue 1, 10-20
download >>

40. T. E. Robinson, Computed Tomography Scanning Techniques for the Evaluation of Cystic Fibrosis Lung Disease, The Proceedings of the American Thoracic Society 4:310-315 (2007)
download >>

41. Martinez FJ, Curtis JL, Sciurba F, Mumford J, Giardino ND, Weinmann G, Kazerooni E, Murray S, Criner GJ, Sin DD, Hogg J, Ries AL, Han M, Fishman AP, Make B, Hoffman EA, Mohsenifar Z, Wise R; National Emphysema Treatment Trial Research Group.Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med. 2007 Aug 1;176(3):243-52. Epub 2007 Apr 12. PubMed PMID: 17431226; PubMed Central PMCID: PMC1994221.
download >>


42. Chon D, Simon BA, Beck KC, Shikata H, Saba OI, Won C, Hoffman EA. Differences in regional wash-in and wash-out time constants for xenon-CT ventilation studies. Respir Physiol Neurobiol. 2005 Aug 25;148(1-2):65-83. PubMed PMID: 16061426.
download >>

43. Palágyi K, Tschirren J, Hoffman EA, Sonka M. Quantitative Analysis of Pulmonary Airway Tree Structures. Comput in Biol and Med. 2006 Sep;36(9):974–996. Epub 2005 Aug 1. PubMed PMID: 16076463.
download >>

44. Tschirren J, Hoffman EA, McLennan G, Sonka M. Intrathoracic airway trees: segmentation and airway morphology analysis from low-dose CT scans. IEEE Trans Med Imaging. 2005 Dec;24(12):1529-39. PubMed PMID: 16353370; PubMed Central PMCID: PMC1851666.
download >>

45. Tschirren J, Hoffman EA, McLennan G, Sonka M. Segmentation and quantitative analysis of intrathoracic airway trees from computed tomography images. Proc Am Thorac Soc. 2005;2(6):484-7, 503-4. PubMed PMID: 16352753; PubMed Central PMCID: PMC2713337.
download >>